I would strongly suggest that Prezi modify its animation approach based on the Apple iOS experience (https://www.theguardian.com/technology/2014/mar/13/apple-iphone-ipad-ios-71-motion-sickness). In addition, Prezi presentations should start with a warning to viewers so that they can leave the presentation if they tend to be susceptible to motion sickness.
Although I can’t read in a moving car and can’t go below in a moving sailboat, I’m otherwise fine with all forms of travel so I never considered myself to be exquisitely sensitive to motion sickness. However, I’ve attended several Prezi presentations and I invariably become nauseated within several minutes. I’ve spoken to several colleagues who also get queasy. (I experienced the same effect with the introduction of Apple iOS7.1 as did a sizeable fraction of other users.)
I would obviously never choose to use Prezi myself and have strongly suggested to colleagues that they avoid it for this reason.
Cool animation is not very cool if it makes you physically ill!